The protease corin regulates electrolyte homeostasis in eccrine sweat glands

M He, T Zhou, Y Niu, W Feng, X Gu, W Xu, S Zhang… - PLoS …, 2021 - journals.plos.org
Sweating is a basic skin function in body temperature control. In sweat glands, salt excretion
and reabsorption are regulated to avoid electrolyte imbalance. To date, the mechanism …

[HTML][HTML] Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice

W Wang, J Shen, Y Cui, J Jiang, S Chen, J Peng… - Kidney international, 2012 - Elsevier
Corin is a protease that activates atrial natriuretic peptide, a cardiac hormone important in
the control of blood pressure and salt–water balance. Here we examined the role of corin in …

Corin: a key mediator in sodium homeostasis, vascular remodeling, and heart failure

X Zhang, X Gu, Y Zhang, N Dong, Q Wu - Biology, 2022 - mdpi.com
Simple Summary Atrial natriuretic peptide (ANP) is an important hormone that regulates
many physiological and pathological processes, including electrolyte and body fluid …

Corin Deficiency Diminishes Intestinal Sodium Excretion in Mice

X Gu, K Wang, W Li, M He, T Zhou, M Liu, Q Wu… - Biology, 2023 - mdpi.com
Simple Summary Sodium homeostasis is critical for body fluid balance. The hormonal
regulation of sodium reabsorption and excretion is central in sodium homeostasis. The …

Function and regulation of corin in physiology and disease

N Dong, Y Niu, Y Chen, S Sun… - Biochemical Society …, 2020 - portlandpress.com
Atrial natriuretic peptide (ANP) is of major importance in the maintenance of electrolyte
balance and normal blood pressure. Reduced plasma ANP levels are associated with the …

Renal corin is essential for normal blood pressure and sodium homeostasis

T Zhou, S Zhang, C Du, K Wang, X Gu, S Sun… - International Journal of …, 2022 - mdpi.com
Atrial natriuretic peptide (ANP)-mediated natriuresis is known as a cardiac endocrine
function in sodium and body fluid homeostasis. Corin is a protease essential for ANP …

Corin deficiency alters adipose tissue phenotype and impairs thermogenesis in mice

X Zhang, W Li, T Zhou, M Liu, Q Wu, N Dong - Biology, 2022 - mdpi.com
Simple Summary Thermoregulation is of fundamental significance for all endothermic
animals. Corin is a protease that activates atrial natriuretic peptide (ANP), a cardiac …

Short-term high-salt diet increases corin level to regulate the salt–water balance in humans and rodents

J Zhang, Y Yin, L Chen, C Chu, Y Wang… - American Journal of …, 2018 - academic.oup.com
BACKGROUND Dietary sodium and potassium affect the fluctuation in blood pressure (BP)
and renal function. Corin, with its enzymatic activity to convert pro-atrial natriuretic peptide …

Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment

N Dong, C Fang, Y Jiang, T Zhou, M Liu, J Zhou… - Journal of Biological …, 2013 - ASBMB
Corin is a cardiac transmembrane serine protease that regulates blood pressure by
activating natriuretic peptides. Corin variants have been associated with African Americans …

[HTML][HTML] Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases

D Polzin, HJ Kaminski, C Kastner, W Wang, S Krämer… - Kidney international, 2010 - Elsevier
Patients with proteinuric kidney diseases often have symptoms of salt and water retention. It
has been hypothesized that dysregulated sodium absorption is due to increased proteolytic …