The transcription factor forkhead box O 3A (FOXO3A) is a tumor suppressor that promotes
cell cycle arrest and apoptosis. Piperlongumine (PL), a plant alkaloid, is known to selectively …

Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-
cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to …

Caffeine is one of the most commonly ingested neuroactive compounds and exhibits
anticancer effects through induction of apoptosis and suppression of cell proliferation …

Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis
are poorly understood. Consequently, we have studied the role of the FoxO transcription …

Cisplatin is one of the major chemotherapeutic agents used against different human
cancers. A better understanding of the downstream cellular targets of cisplatin will provide …

Hepatocellular carcinoma (HCC) is one of the most common malignancy-related deaths.
p53 mutation in HCC associates with worse clinicopathologic features including therapeutic …

Abstract Forkhead box O4 (FOXO4) has been reported to be a novel tumor suppressor gene
in gastrointestinal cancers; however, its role in clear‑cell renal carcinoma cells (ccRCC) has …

The anthraquinone compound rhein is a natural agent in the traditional Chinese medicine
rhubarb. Preclinical studies demonstrate that rhein has anticancer activity. Treatment of a …

In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell
lines as model systems to investigate the molecular mechanisms whereby STI571 and …

The oncogenic transcription factor Forkhead box M1 (FoxM1) is overexpressed in many
human tumors, including glioma. As a critical regulator of the cell cycle and apoptosis …