The pathological sequence for type 2 diabetes is complex and entails many different
elements that act in concert to cause that disease. This review proposes a sequence of …

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes: Cell Skip
to Main Content Advertisement Cell This journal offers authors two options (open access or …

Pathogenesis of Type 2 Diabetes Page 1 2 Pathogenesis of Type 2 Diabetes Michael Stumvoll
Department of Medicine, University of Leipzig, Leipzig, Germany Barry J. Goldstein Division of …

Type 2 Diabetes results from a complex physiologic process that includes the pancreatic
beta cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and …

Following an overnight fast the majority of glucose disposal occurs in insulin-independent
tissues, the brain (-50%) and splanchnic organs (-25%), while only 25% occurs in insulin …

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in
carbohydrate and fat metabolism. The causes of type 2 diabetes are multifactorial and …

Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing
pancreatic beta-cells leads to increased blood sugar levels. Both genetic and environmental …

Type 2 diabetic patients are insulin resistant as a result of obesity and a sedentary lifestyle.
Nevertheless, it has been known for the past five decades that insulin response to nutrients …

Type 1 diabetes is a complex disease involving a combination of factors, such as genetic
susceptibility, immunologic dysregulation and exposure to environmental triggers. Animal …

The purpose of this article is to provide an overview that summarizes much in the way of our
current state of knowledge regarding the pathogenesis and natural history of type 1 diabetes …