The aging process is associated with a loss of complexity in the dynamics of physiological
systems that reduce the ability to adapt to stress, causing frailty and/or age-related diseases …

Cellular senescence is a definable fate of cells within aging, diseased, and remodelling
tissues. The traditional hallmark of cellular senescence is permanent cell cycle arrest but the …

Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …

Aging is a major risk factor of atherosclerosis through different complex pathways including
replicative cellular senescence and age-related clonal hematopoiesis. In addition to aging …

Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is
hallmarked by a progressive decrease in cell growth, differentiation, and biological activities …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle
continually. Instead, they eventually show an irreversible arrest of proliferation, commonly …

Atherosclerosis is an age-related disorder associated with long-term exposure to
cardiovascular risk factors. The asymptomatic progression of atherosclerotic plaques leads …

Cardiovascular disease is currently the largest cause of mortality and disability globally,
surpassing communicable diseases, and atherosclerosis is the main contributor to this …

Replicative capacity of somatic cells is limited. It indicates that aging also develops at the
cellular level, and this is described as “cellular senescence”. Senescent cells become …