Semaphorins are the products of a large gene family containing 28 genes of which 21 are
found in vertebrates. Class-3 semaphorins constitute a subfamily of seven vertebrate …

The semaphorins were initially described as axon guidance factors, but have recently been
implicated in a variety of physiological and developmental functions, including regulation of …

The semaphorins were initially characterized as repulsive axon guidance factors. However,
they are currently also recognized as important regulators of diverse biological processes …

The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …

The semaphorins are the products of a large family of genes currently containing more than
30 members. These genes are divided into eight classes of which classes 1, 2 and 8 contain …

The neuropilins were originally characterized as cell membrane receptors that bind axon
guidance factors belonging to the class-3 semaphorin subfamily. To transduce semaphorin …

The class-3 semaphorins (sema3s) include seven family members. Six of them bind to
neuropilin-1 (np1) or neuropilin-2 (np2) receptors or to both, while the seventh, sema3E …

Semaphorins are regulatory molecules that are linked to the modulation of several cancer
processes, such as angiogenesis, cancer cell invasiveness and metastasis, tumor growth …

Simple Summary Cancer is the second leading cause of death in the US. In 2023,
approximately 609,820 deaths from cancer are expected. Plexins are a family of receptors …

Class 3 semaphorins (Sema3) are a family of secreted proteins that were originally identified
as axon guidance factors mediating their signal transduction by forming complexes with …