Tissue-to-plasma water partition coefficients (Kpu's) form an integral part of whole body
physiologically based pharmacokinetic (WBPBPK) models. This research aims to improve …

A key component of whole body physiologically based pharmacokinetic (WBPBPK) models
is the tissue-to-plasma water partition coefficients (Kpu's). The predictability of K pu values …

Purpose To use recently developed mechanistic equations to predict tissue-to-plasma water
partition coefficients (Kpus), apply these predictions to whole body unbound volume of …

Background The major aim of this study was to develop a strategy for predicting human
pharmacokinetics using physiologically based pharmacokinetic (PBPK) modelling. This was …

The tissue: plasma (P t: p) partition coefficients (PCs) are important drug‐specific input
parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the …

Physiologically based pharmacokinetic (PBPK) models are composed of a series of
differential equations and have been implemented in a number of commercial software …

Conventional mammillary models are frequently used for pharmacokinetic (PK) analysis
when only blood or plasma data are available. Such models depend on the quality of the …

Many in vitro data on physicochemical properties and specific absorption, distribution,
metabolism, and elimination (ADME) processes are already available at early stages of drug …

The present paper proposes a modeling and simulation strategy for the prediction of
pharmacokinetics (PK) of drug candidates by using currently available in silico and in vitro …

The aim of the current review is to summarise the present status of physiologically based
pharmacokinetic (PBPK) modelling and its applications in drug research, and thus serve as …