When embryonic rat hippocampal neurons were cultured in a 50% oxygen atmosphere,
neurons gradually died after 20 h in culture. This death pattern was found to be mediated by …

A high oxygen atmosphere induced apoptosis in cultured neuronal cells including PC12
cells and rat embryonic cortical, hippocampal, and basal forebrain neurons associated with …

Apoptosis has been recently implicated in the dying process of neurons under several
pathological conditions including ischemia. However, although apoptosis was originally …

Cerebral hypoxia/ischemia was shown to induce delayed, apoptotic neuronal death
occurring through biochemical pathways potentially sharing common events with cell …

In various animal models of cerebral hypoxia–ischemia, it is not clear whether neuronal
apoptosis results from hypoxia alone or whether other factors mediate this process. We …

Protein synthesis inhibitors have recently been shown to protect from ischemia-induced
neuronal death in the rat hippocampus in vivo. In an attempt to further investigate the …

Oxygen-induced cell death in embryonic neurons is a useful in vitro model of neuronal
apoptosis to study the molecular mechanisms underlying the cell death induced by oxidative …

To investigate whether direct oxidative damage may induce neuronal death via an apoptotic
cell suicide pathway, we exposed cultured cortical neurons to the prooxidant hydrogen …

We previously reported that PC12h cells are killed by a high oxygen atmosphere. In this
study, we further characterized this oxygen-induced cell death and found apoptotic features …

We have attempted to elucidate the mechanism of apoptotic cell death induced by hypoxia
(very low oxygen conditions) in neuronal cells. Human neuroblastoma SK-N-MC cells under …