The pathology of human spinal cord injury: defining the problems

MD Norenberg, J Smith, A Marcillo - Journal of neurotrauma, 2004 - liebertpub.com
This article reviews the pathology of human spinal cord injury (SCI), focusing on potential
differences between humans and experimental animals, as well as on aspects that may …

Pathophysiology of spinal cord injury

LD Hachem, MG Fehlings - Neurosurgery Clinics, 2021 - neurosurgery.theclinics.com
Spinal cord injury (SCI) triggers a complex cascade of molecular and chemical events that
leads to progressive cell loss and tissue damage. 1, 2 Nearly a century of fundamental basic …

Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Harmful and beneficial effects of inflammation after spinal cord injury: potential therapeutic implications

S David, R López-Vales, VW Yong - Handbook of clinical neurology, 2012 - Elsevier
Spinal cord injury (SCI) results in immediate damage followed by a secondary phase of
tissue damage that occurs over a period of several weeks. The mechanisms underlying this …

Degenerative and regenerative mechanisms governing spinal cord injury

C Profyris, SS Cheema, DW Zang, MF Azari… - Neurobiology of …, 2004 - Elsevier
Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …

Current developments in spinal cord injury research

GD Carlson, C Gorden - The Spine Journal, 2002 - Elsevier
Background context: Recent advances in neuroscience have opened the door for hope
toward prevention and cure of the devastating effects of spinal cord injury (SCI). Purpose: To …

The unique histopathological responses of the injured spinal cord: implications for neuroprotective therapy

L Guth, Z Zhang, O Steward - Annals of the New York Academy …, 1999 - Wiley Online Library
Tissue destruction at the primary site of a spinal cord injury leads to persistent necrosis that
progressively enlarges the lesion. Steroids attenuate this necrotizing process and promote …

Recent update on basic mechanisms of spinal cord injury

SA Quadri, M Farooqui, A Ikram, A Zafar, MA Khan… - Neurosurgical …, 2020 - Springer
Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …

Spinal cord injury: review of basic and applied research

JC De La Torre - Spine, 1981 - journals.lww.com
This review examines, in a condensed manner, many of the major achievements related to
spinal cord injury research during the last quarter century. Most of the advances have been …