We recently reported the identification of a novel human adenosine A3 receptor-selective
agonist,(2 S, 3 S, 4 R, 5 R)-3-amino-5-{6-[5-chloro-2-(3-methylisoxazol-5-ylmethoxy) …

Adenosine is an endogenous nucleoside that plays a major role in the physiology and
physiopathology of the coronary artery system, mainly by activating its A2A receptors …

ATP-sensitive K-channels (K (ATP)) play a major role in controlling blood vessel tone,
particularly in coronary vasculature. Arachidonic acid (AA) exhibits potent vasorelaxant …

Cyclic adenosine diphosphate ribose and adenosine diphosphate ribose (ADPR) play an
important role in the regulation of intracellular Ca 2+ release and K+ channel activity in the …

Isolated aortic rings (endothelium‐intact and‐denuded) from spontaneously hypertensive
(SHR) and Wistar‐Kyoto (WKY) rats were used in this study to examine the vasoactive …

In this study, we investigated the effect of noradrenaline depletion on contractile recovery in
rat isolated heart following myocardial ischaemia. Groups tested included control tissues …

The authors sought to demonstrate the advantages of a selective, potent, short-acting A 2A
adenosine receptor agonist, CVT-3146 (2-(N-pyrazolyl) Ado derivative), for potential clinical …

Because adenosine is a vascular tone modulator, we examined the effect of adenosine and
congeners in the vascular reactivity of isolated human placental vessels and in perfused …

Abstract Adenosine A 2A receptor (A 2A AR) activation plays a major role in the regulation of
coronary flow (CF). Recent studies from our laboratory and others have suggested that A 2A …

Coronary vasolidator mechanisms of adenosine were investigated in isolated canine
papillary muscle preparations cross-circulated through the anterior septal artery with support …