Objectives Cilnidipine is a calcium channel blocker that blocks both L and N-type calcium
channels. L/N-type calcium channel blockers exhibit sympatholytic action and a renal …

Cilnidipine inhibits both L-and N-type calcium channels and has been shown to dilate
efferent arterioles as effectively as afferent arterioles. We conducted an open-label …

Objective: The L/N-type calcium channel blocker (CCB) cilnidipine suppresses sympathetic
nerve activity and has a superior renoprotective effect compared with L-type CCBs such as …

Background: Clinical research in the field of hypertension is now increasingly focusing on
the potential effects of antihypertensive treatments that may go beyond the reduction of …

Cilnidipine is a novel dihydropyridine (DHP) antagonist. However, its pharmacological
effects on vascular DHP-sensitive L-type channels and protein kinase C (PKC)-mediated …

Cilnidipine is an L/N‐type calcium channel blocker (CCB). The effects of cilnidipine on N‐
type channels give it unique organ‐protective properties via the suppression of hyperactivity …

Hypertension, by definition, is a hemodynamic disorder. A high cardiac output and a normal
systemic vascular resistance characterize the young hypertensive patient. As hypertension …

Introduction: Hypertension is one of the most common cardiovascular diseases, and the
prevalence of hypertension continues to rise across the globe. National and international …

Cilnidipine is a novel and unique 1, 4-dydropyridine derivative calcium antagonist that
exerts potent inhibitory actions not only on L-type but also on N-type voltage-dependent …

Systemic hypertension is a major global problem contributing to enormous disease burden,
premature morbidity and mortality. A substantial majority of hypertensive patients require …