Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past …

Androgens are essential for male development and the maintenance of male secondary
characteristics, such as bone mass, muscle mass, body composition, and spermatogenesis …

Androgen receptor (AR) plays a critical role in the function of several organs including
primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable …

Introduction: The development and potential clinical use of tissue-selective androgen
receptor modulators (SARMs) have advanced tremendously over the past few years. A key …

Selective androgen receptor modulators (SARMs) are small molecule drugs that function as
either androgen receptor (AR) agonists or antagonists. Variability in AR regulatory proteins …

Selective androgen receptor modulators (SARMs) are a novel class of androgen receptor
(AR) ligands that might change the future of androgen therapy dramatically. With improved …

A series of nonsteroidal ligands were synthesized as second-generation agonists for the
androgen receptor (AR). These ligands were designed to eliminate metabolic sites identified …

Androgen therapy, using injectable, oral and more recently, transdermal preparations, has
been available to physicians for many years to treat a variety of male disorders; to a lesser …

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor
Modulator (SARM) RAD140 | ACS Medicinal Chemistry Letters ACS ACS Publications C&EN …