The human androgen receptor (AR) is considered as a master regulator in the development
and progression of prostate cancer (PCa). As resistance to clinically used anti-AR drugs …

Steroids can induce both transcription-dependent (genomic) and independent
(nongenomic) signaling. Here, several classical androgen receptor ligands were tested for …

Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of
prostate development and homeostasis. Frontline therapies for metastatic PC deprive the …

Androgen receptor (AR) is closely associated with a group of hormone‐related diseases
including the cancers of prostate, breast, ovary, pancreas, etc and anabolic deficiencies …

Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

Several remarkable advances in androgen phar-macology during the last decade, including
better understanding of the pharmacokinetics of testosterone esters and the development of …

In our effort to find small-molecule treatments of advanced prostate cancers (PCs), a novel
series of indolyl and indolinyl propanamides (series II and III) were discovered as selective …

Prostate cancer (PCa) and breast cancer (BCa) share similarities as hormone-sensitive
cancers with a wide heterogeneity of both phenotype and biology. The androgen receptor …

The androgen receptor (AR) is a nuclear receptor transcription factor that mediates the
cellular actions of androgens, the male sex steroids. Androgen-dependent tissues, such as …

The androgen receptor (AR) is a ligand-regulated transcription factor that belongs to the
family of nuclear receptors. In addition to regulation by steroid, the AR is also regulated by …