Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development
RM Barnes, BA Firulli, NJ VanDusen… - Circulation …, 2011 - Am Heart Assoc
Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …
essential for embryonic development. Given their requirement for cardiogenesis, it is …
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
DG McFadden, AC Barbosa, JA Richardson… - 2005 - journals.biologists.com
The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects
JW Vincentz, RM Barnes… - Birth Defects Research Part …, 2011 - Wiley Online Library
Almost 15 years of careful study have established the related basic Helix‐Loop‐Helix
(bHLH) transcription factors Hand1 and Hand2 as critical for heart development across …
(bHLH) transcription factors Hand1 and Hand2 as critical for heart development across …
[PDF][PDF] Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium
NJ VanDusen, J Casanovas, JW Vincentz, BA Firulli… - Cell reports, 2014 - cell.com
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure
BA Firulli, RM George, J Harkin, KP Toolan… - Cardiovascular …, 2020 - academic.oup.com
Aims To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
[HTML][HTML] Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function
JW Vincentz, KP Toolan, W Zhang, AB Firulli - PLoS genetics, 2017 - journals.plos.org
Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for
heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play …
heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play …
Hand factors in cardiac development
RM George, AB Firulli - The Anatomical Record, 2019 - Wiley Online Library
Congenital heart defects account for 1% of infant mortality and 10% of in utero deaths. As
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …
the vertebrate embryo develops, multiple tissue types develop in tandem to morphologically …
A functional genetic study identifies HAND1 mutations in septation defects of the human heart
SM Reamon-Buettner, Y Ciribilli… - Human molecular …, 2009 - academic.oup.com
Heart and neural crest derivatives expressed 1 (HAND1) is a basic helix-loop-helix (bHLH)
transcription factor essential for mammalian heart development. Absence of Hand1 in mice …
transcription factor essential for mammalian heart development. Absence of Hand1 in mice …
[HTML][HTML] Hand2 function in second heart field progenitors is essential for cardiogenesis
Cardiogenesis involves the contributions of multiple progenitor pools, including mesoderm-
derived cardiac progenitors known as the first and second heart fields. Disruption of genetic …
derived cardiac progenitors known as the first and second heart fields. Disruption of genetic …