The accurate assembly of signalosomes centered on the adaptor protein LAT (linker of
activated T cells) is required for antigen receptor signaling in T cells and mast cells. During …

Antigen receptor signaling pathways are organized by adaptor proteins. Three adaptors,
LAT, Gads, and SLP-76, form a heterotrimeric complex that mediates signaling by the T cell …

The Grb2-like adaptor protein GADS is essential for tyrosine kinase-dependent signaling in
T lymphocytes. Following T cell receptor ligation, GADS interacts through its C-terminal SH3 …

The transmembrane protein, linker for activation of T cells (LAT), is essential for T‐cell
activation and development. Phosphorylation of LAT at multiple tyrosines creates binding …

Receptor oligomerization is vital for activating intracellular signaling, in part by initiating
events that recruit effector and adaptor proteins to sites of active signaling. Whether these …

A critical event in T cell receptor (TCR)-mediated signaling is the recruitment of
hematopoietic-specific adaptor proteins that collect and transmit signals downstream of the …

Transmembrane adaptor molecule LAT (linker for activation of T cells) forms a central
scaffold for signaling protein complexes that accumulate in the vicinity of activated T cell …

The Grb2-related adaptor protein GADS plays a central role during the initial phases of
signal transduction in T lymphocytes. GADS possesses N-and C-terminal Src homology 3 …

T cells are essential for the adaptive immune response to pathogens. However,
dysfunctional T cell activity has been implicated in numerous diseases, including the failure …

Abstract Background: The adaptor protein Gads is a Grb2-related protein originally identified
on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein …