The molecular switching mechanism governing skeletal and cardiac muscle contraction
couples the binding of Ca2+ on troponin to the movement of tropomyosin on actin filaments …

The molecular regulation of striated muscle contraction couples the binding and dissociation
of Ca2+ on troponin (Tn) to the movement of tropomyosin on actin filaments. In turn, this …

In a wide variety of cellular settings, from organelle transport to muscle contraction, Ca2+
binding to members of the EF hand family of proteins controls the interaction between actin …

Troponin and tropomyosin on actin filaments constitute a Ca2+-sensitive switch that
regulates the contraction of vertebrate striated muscle through a series of conformational …

The contraction of skeletal muscle is regulated by Ca 2+ binding to troponin C, which results
in an internal reorganization of the interactions within the troponin-tropomyosin complex …

The steric model of muscle regulation holds that at low Ca2+ concentration, tropomyosin
strands, running along thin filaments, are constrained by troponin in an inhibitory position …

REGULATION BY TROPONIN-TROPOMYOSIN 537 structural changes cause increased
interaction between actin and myosin, enhanced actomyosin ATPase activity, and …

Tropomyosin, controlled by troponin-linked Ca 2+-binding, regulates muscle contraction by
a macromolecular scale steric-mechanism that governs myosin-crossbridge–actin …

Rationale: Ca2+ control of troponin–tropomyosin position on actin regulates cardiac muscle
contraction. The inhibitory subunit of troponin, cardiac troponin (cTn) I is primarily …

Recently, our understanding of the structural basis of troponin-tropomyosin's Ca 2+-
triggered regulation of striated muscle contraction has advanced greatly, particularly via cryo …