Therapeutic genome editing in cardiovascular diseases

M Nishiga, LS Qi, JC Wu - Advanced drug delivery reviews, 2021 - Elsevier
During the past decade, developments in genome editing technology have fundamentally
transformed biomedical research. In particular, the CRISPR/Cas9 system has been …

Therapeutic genome editing in cardiovascular diseases

DM German, S Mitalipov, A Mishra, S Kaul - JACC: Basic to Translational …, 2019 - jacc.org
A variety of genetic cardiovascular diseases may one day be curable using gene editing
technology. Germline genome editing and correction promises to permanently remove …

Genome editing in cardiovascular diseases

A Strong, K Musunuru - Nature Reviews Cardiology, 2017 - nature.com
Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-
like effector nucleases (TALENs), and clustered regularly interspaced short palindromic …

Genome editing technology: A new frontier for the treatment and prevention of cardiovascular diseases

S Saeed, SU Khan, WU Khan… - Current Problems in …, 2023 - Elsevier
Over the past 2 decades, genome-editing technique has proven to be a robust editing
method that revolutionizes the field of biomedicine. At the genetic level, it can be efficiently …

The impact of CRISPR/Cas9 technology on cardiac research: from disease modelling to therapeutic approaches

BM Motta, PP Pramstaller, AA Hicks… - Stem cells …, 2017 - Wiley Online Library
Genome‐editing technology has emerged as a powerful method that enables the generation
of genetically modified cells and organisms necessary to elucidate gene function and …

Gene editing in common cardiovascular diseases

AM Lauerer, XM Caravia, LS Maier, F Chemello… - Pharmacology & …, 2024 - Elsevier
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide,
highlighting the high socioeconomic impact. Current treatment strategies like compound …

Translating genomic insights into cardiovascular medicine: Opportunities and challenges of CRISPR-Cas9

Y Zhang, I Karakikes - Trends in cardiovascular medicine, 2021 - Elsevier
The growing appreciation of human genetics and genomics in cardiovascular disease
(CVD) accompanied by the technological breakthroughs in genome editing, particularly the …

Gene editing therapy for cardiovascular diseases

X Wu, J Yang, J Zhang, Y Song - MedComm, 2024 - Wiley Online Library
The development of gene editing tools has been a significant area of research in the life
sciences for nearly 30 years. These tools have been widely utilized in disease detection and …

The use of new CRISPR tools in cardiovascular research and medicine

M Nishiga, C Liu, LS Qi, JC Wu - Nature Reviews Cardiology, 2022 - nature.com
Many novel CRISPR-based genome-editing tools, with a wide variety of applications, have
been developed in the past few years. The original CRISPR–Cas9 system was developed …

Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research

ZH Li, J Wang, JP Xu, J Wang, X Yang - Military Medical Research, 2023 - Springer
The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …