Immunohistochemical localization of oxytocin receptors in human brain

ML Boccia, P Petrusz, K Suzuki, L Marson… - Neuroscience, 2013 - Elsevier
The neuropeptide oxytocin (OT) regulates rodent, primate and human social behaviors and
stress responses. OT binding studies employing 125 Id (CH 2) 5-[Tyr (Me) 2, Thr 4, Tyr-NH 2 …

Switching brain serotonin with oxytocin

R Mottolese, J Redouté, N Costes… - Proceedings of the …, 2014 - National Acad Sciences
Serotonin (5-HT) and oxytocin (OXT) are two neuromodulators involved in human affect and
sociality and in disorders like depression and autism. We asked whether these chemical …

Homo‐and hetero‐dimeric complex formations of the human oxytocin receptor

D Devost, HH Zingg - Journal of neuroendocrinology, 2004 - Wiley Online Library
Using two different coimmunoprecipitation strategies as well as bioluminescence resonance
energy transfer (BRET) techniques, we determined that the human oxytocin receptor forms …

Roles of the oxytocin receptor (OXTR) in human diseases

K Pierzynowska, L Gaffke, M Żabińska, Z Cyske… - International journal of …, 2023 - mdpi.com
The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal
transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in …

Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization

PK Wrzal, D Devost, D Pétrin, E Goupil, C Iorio-Morin… - Cellular signalling, 2012 - Elsevier
The oxytocin receptor (OTR) and the β2-adrenergic receptor (β2AR) are key regulators of
uterine contraction. These two receptors are targets of tocolytic agents used to inhibit pre …

[HTML][HTML] Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse

EAD Hammock, P Levitt - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Oxytocin (OXT) has drawn increasing attention as a developmentally relevant neuropeptide
given its role in the brain regulation of social behavior. It has been suggested that OXT plays …

Non-peptide oxytocin agonists

G Pitt, A Batt, R Haigh, A Penson, P Robson… - Bioorganic & medicinal …, 2004 - Elsevier
A library of compounds targeted to the vasopressin/oxytocin family of receptors was
screened for activity at a cloned human oxytocin receptor using a reporter gene assay …

[HTML][HTML] Oxytocin and social motivation

I Gordon, C Martin, R Feldman, JF Leckman - Developmental cognitive …, 2011 - Elsevier
Humans are fundamentally social creatures who are 'motivated'to be with others. In this
review we examine the role of oxytocin (OT) as it relates to social motivation. OT is …

Sex differences in the embryonic development of the central oxytocin system in mice

S Tamborski, EM Mintz… - Journal of …, 2016 - Wiley Online Library
Recent studies suggest that oxytocin (OXT) may be important for organising the neural
circuitry that underlies adult social behaviour. Although most of the work exploring these …

Oxytocin as a potential mediator and modulator of drug addiction

Z Sarnyai - Addiction Biology, 2011 - researchonline.jcu.edu.au
[Extract] Oxytocin, a nine amino acid neuropeptide, first discovered by Sir Heury Dale in
1906, is a potent modulator of a variety of brain functions including emotions, mood, social …