Oxytocin: an old hormone, a novel psychotropic drug and its possible use in treating psychiatric disorders
Background: Oxytocin is a nonapeptide synthesized in the paraventricular and supraoptic
nuclei of the hypothalamus. Historically, this molecule has been involved as a key factor in …
nuclei of the hypothalamus. Historically, this molecule has been involved as a key factor in …
An overview of the oxytocin-oxytocin receptor signaling network
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the
hypothalamus and stored and released from the neural lobe of the pituitary gland. Although …
hypothalamus and stored and released from the neural lobe of the pituitary gland. Although …
In vitro pharmacological profile of a novel structural class of oxytocin antagonists.
DJ Pettibone, BV Clineschmidt, EV Lis, DR Reiss… - … of Pharmacology and …, 1991 - ASPET
A number of structurally novel cyclic hexapeptides have been characterized as potent and
selective oxytocin (OT) antagonists in vitro. As a representative of this class of compounds, L …
selective oxytocin (OT) antagonists in vitro. As a representative of this class of compounds, L …
[HTML][HTML] Brain oxytocin: how puzzle stones from animal studies translate into psychiatry
V Grinevich, ID Neumann - Molecular psychiatry, 2021 - nature.com
The neuropeptide oxytocin has attracted great attention of the general public, basic
neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social …
neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social …
Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
RH Ring, LE Schechter, SK Leonard, JM Dwyer… - …, 2010 - Elsevier
The widely reported effects of oxytocin (OT) on CNS function has generated considerable
interest in the therapeutic potential for targeting this system for a variety of human psychiatric …
interest in the therapeutic potential for targeting this system for a variety of human psychiatric …
[3H]-[Thr4, Gly7] OT: a highly selective ligand for central and peripheral OT receptors
J Elands, C Barberis, S Jard - American Journal of …, 1988 - journals.physiology.org
Oxytocin receptors in rat hippocampal synaptic plasma membranes were compared with
mammary gland and uterine oxytocin receptors. For this purpose, a highly specific oxytocic …
mammary gland and uterine oxytocin receptors. For this purpose, a highly specific oxytocic …
Oxytocin in health and disease
N Tom, SJ Assinder - The international journal of biochemistry & cell …, 2010 - Elsevier
Oxytocin is a nonapeptide of the neurohypophyseal protein family that binds specifically to
the oxytocin receptor to produce a multitude of central and peripheral physiological …
the oxytocin receptor to produce a multitude of central and peripheral physiological …
Intracellular trafficking of the human oxytocin receptor: evidence of receptor recycling via a Rab4/Rab5 “short cycle”
F Conti, S Sertic, A Reversi… - American Journal of …, 2009 - journals.physiology.org
As in the case of most G protein-coupled receptors, agonist stimulation of human oxytocin
receptors (OTRs) leads to desensitization and internalization; however, little is known about …
receptors (OTRs) leads to desensitization and internalization; however, little is known about …
Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour
T Onaka, Y Takayanagi… - Journal of …, 2012 - Wiley Online Library
Oxytocin neurones are activated by stressful stimuli, food intake and social attachment.
Activation of oxytocin neurones in response to stressful stimuli or food intake is mediated, at …
Activation of oxytocin neurones in response to stressful stimuli or food intake is mediated, at …
Novel oxytocin receptor agonists and antagonists: a patent review (2002–2013)
Y Yang, H Li, R Ward, L Gao, JF Wei… - Expert Opinion on …, 2014 - Taylor & Francis
Introduction: Oxytocin is a nine amino acid cyclic peptide hormone with a high degree of
uterotonic activity. The oxytocin receptor (Oxtr) is most strongly expressed in the uterus and …
uterotonic activity. The oxytocin receptor (Oxtr) is most strongly expressed in the uterus and …