Structural analyses of toll-like receptor 7 reveal detailed RNA sequence specificity and recognition mechanism of agonistic ligands

Z Zhang, U Ohto, T Shibata, M Taoka, Y Yamauchi… - Cell reports, 2018 - cell.com
Summary Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA
(ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 …

Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system

MG Netea, C Van der Graaf… - Journal of Leucocyte …, 2004 - academic.oup.com
Toll-like receptors (TLRs) have been identified as a major class of pattern-recognition
receptors. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, alone …

Toll receptors: an expanding role in our understanding of human disease

JM Schuster, PS Nelson - Journal of Leukocyte Biology, 2000 - academic.oup.com
Toll receptor proteins in Drosophila are involved in establishing the dorsal-ventral axis in
embryogenesis as well as participating in the innate immune response to invading …

Regulation of Toll‐like receptor signaling pathways in innate immune responses

C Qian, X Cao - Annals of the New York Academy of Sciences, 2013 - Wiley Online Library
Toll‐like receptors (TLRs) are critical pattern recognition receptors (PRRs) that recognize
pathogen‐associated molecular patterns (PAMPs), which are conserved and specific …

Toll-like receptor signaling pathways

GM Barton, R Medzhitov - Science, 2003 - science.org
Members of the Toll-like receptor (TLR) family recognize conserved microbial structures,
such as bacterial lipopolysaccharide and viral double-stranded RNA, and activate signaling …

Targeting Toll-like receptors with small molecule agents

X Wang, C Smith, H Yin - Chemical Society Reviews, 2013 - pubs.rsc.org
Toll-like receptors (TLRs) are type I transmembrane proteins that are key regulators of both
innate and adaptive immune responses. To protect the host from viral and bacterial threats …

The Toll-like receptors and their role in septic shock

P Cristofaro, SM Opal - Expert opinion on therapeutic targets, 2003 - Taylor & Francis
The Toll-like receptors (TLRs) are a class of pattern recognition molecules with unique
functions in the innate and the acquired immune systems. The innate immune response has …

Update on the role of Toll-like receptors during bacterial infections and sepsis.

S Knapp - Wiener medizinische Wochenschrift (1946), 2010 - europepmc.org
Toll-like receptors (TLRs) are recognition molecules that importantly contribute to the innate
immune response to bacterial and viral infections. Once TLRs sense the presence of …

TLR2 as a therapeutic target in bacterial infection

ME Simpson, WA Petri Jr - Trends in molecular medicine, 2020 - Elsevier
Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections
and can influence the downstream immune response to the host's benefit or detriment …

The use of toll-like receptor agonists in HIV-1 cure strategies

JT Martinsen, JD Gunst, JF Højen, M Tolstrup… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptors (TLRs) are a family of pattern recognition receptors and part of the first
line of defense against invading microbes. In humans, we know of 10 different TLRs, which …