Monoclonal antibodies (MAbs) recognizing tumor-associated antigens (TAA) have been
widely used to selectively deliver toxic compounds to neoplastic cells. In most studies, tumor …

Rap, a single-chain ribonuclease originally isolated from the oocytes of Rana pipiens,
exhibits cytostatic and cytotoxic effects on a variety of tumor cell lines in vitro, as well as …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

The use of chemotherapeutic drugs in combination with bone marrow transplantation to treat
cancer patients has markedly improved the disease-free survival and cure rate. Part of the …

Drug targeting is an attractive new approach to killing malignant cells, thereby leaving
normal tissue unharmed. A decisive breakthrough was the advent of hybridoma technology …

This review presents only those contributions that have progressed from the bench to the
clinic using murine monoclonal antibodies coupled chemically to toxins, their subunits or …

Ribonucleases (RNase) are potential anti-tumor agents, and their potency can be enhanced
by recombinant fusion or chemical conjugation with tumor-targeting antibodies, as have …

In this study, we compared the ability of different bispecific monoclonal antibodies (BsmAb)
and immunotoxins to deliver the type 1 ribosome-inactivating proteins (RIP) saporin and …

Antibodies linked to cytotoxic compounds were designed to kill diseased cells while sparing
normal ones. The benefits of this “smart drug” approach has great appeal and attempts at …

Conjugates of antibodies with plant toxins, such as ricin and abrin, are potent cytotoxic
agents that selectively eliminate target cells from mixed cell cultures in vitro, and have great …