Background: A number of synthetic steroids are capable of modulating progesterone
receptors with a spectrum of activities ranging from pure antagonism to a mixture of agonism …

Background: Synthetic compounds can bind to progesterone receptors and these
progesterone receptor ligands exhibit a spectrum of activities ranging from pure antagonism …

Since the original description of the structure of the antiprogestin, mifepristone, was
published, numerous related compounds have been synthesized which may function as …

Among the remarkable progress made in the treatment of hormone-dependent diseases,
recently selective steroid receptor modulators (SPRM) have been remarkable tools to …

Since the discovery of the antiprogestin mifepristone, hundreds of similar compounds have
been synthesized, which can be grouped in a large family of progesterone receptor ligands …

Progesterone antagonists belong to the family of selective progesterone receptor
modulators. SPRMs already have several applications in women's health. Their main value …

Since the discovery of the progesterone receptor antagonist mifepristone, numerous
additional compounds, which display a spectrum of biological actions ranging from full …

Since the description of the structure of the first progesterone receptor antagonist,
mifepristone, was published, numerous related compounds have been synthesized, which …

Org 31710 and Org 33628 are two highly selective progesterone receptor modulators
(PRMs) with respect to their anti-progestational and anti-glucocorticoid activity. The …

Introduction Patients with various advanced cancers devoid of nuclear progesterone
receptors (nPR) have demonstrated increased quality and length of life when treated with …