Background: Ribosome-inactivating proteins (RIPs) are wildly found in multiple species of
plants, bacteria and fungi. As a special family of protein toxins, RIPs can inhibit protein …

The term ribosome-inactivating protein (RIP) is used to denominate proteins mostly of plant
origin, which have N-glycosidase enzymatic activity leading to a complete destruction of the …

Most molecular target-based therapeutic research facilities use two basic techniques:
protein-kinase inhibitors and monoclonal antibodies. However, they continue to face …

Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a
targeting domain coupled chemically or genetically to a proteinaceous toxin payload. The …

Ribosome-inactivating proteins (RIPs) are enzymes (3.2. 2.22) that possess N-glycosilase
activity that irreversibly inhibits protein synthesis. RIPs have been found in plants, fungi …

The concept of “magic bullets”, ie, drugs able to selectively act on target cells, formulated by
Paul Ehrlich more than one century ago, gave rise to the idea of immunotargeting, one of the …

Immunotoxins are chimeric proteins obtained by linking a toxin to either an intact antibody or
an antibody fragment. Conjugation can be obtained by chemical or genetic engineering …

Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been
used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the …

Monoclonal antibodies (MAbs) recognizing tumor-associated antigens (TAA) have been
widely used to selectively deliver toxic compounds to neoplastic cells. In most studies, tumor …

Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic
payloads to selectively eliminate tumor cells. This payload can be either a synthetic small …