Activation of hepatic stellate cells (HSCs) is a pivotal cellular event in liver fibrosis.
Therefore, improving our understanding of the molecular pathways that are involved in these …

Liver fibrosis is a life-threatening disease, with challenging morbidity and mortality for
healthcare systems worldwide. It imparts an enormous economic burden to societies …

Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by
diminished adipogenic transcription. This study investigated whether Wnt signaling …

Cirrhosis is a form of liver fibrosis resulting from chronic hepatitis and caused by various liver
diseases, including viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis, and …

BACKGROUND/AIMS: Liver fibrosis is characterized by accumulation of extracellular matrix
proteins synthesized by activated hepatic stellate cells (HSCs). To understand molecular …

AIM: To identify differentially expressed genes in quiescent and activated hepatic stellate
cells (HSCs) and explore their functions. METHODS: HSCs were isolated from the normal …

Liver fibrosis is a common wound-healing response to chronic liver injuries, including
alcoholic or drug toxicity, persistent viral infection, and genetic factors. Myofibroblastic …

Abstract β‑catenin, a core component of Wnt/β‑catenin signaling, has been shown to be an
important regulator of cellular proliferation and differentiation. Abnormal activation of Wnt/β …

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver
disease, the long-term loss of hepatocytes often leads to adverse consequences such as …

Quiescent hepatic stellate cells (HSCs), in response to liver injury, undergo characteristic
morphological transformation into proliferative, contractile and ECM-producing …