Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

Alterations in the abundance or activities of alternative splicing regulators generate
alternatively spliced variants that contribute to multiple aspects of tumor establishment …

Alternative splicing is a key molecular mechanism for increasing the functional diversity of
the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in …

Alternative pre-mRNA splicing is a key molecular event that allows for protein diversity.
Through this process, a single gene increases its coding capacity by expressing several …

Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …

Recent progress in global sequence and microarray data analysis has revealed the
increasing complexity of the human transcriptome. Alternative splicing generates a huge …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Alternative splicing of mRNA precursors enables one gene to produce multiple protein
isoforms with differing functions. Under normal conditions, this mechanism is tightly …

Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …