In vitro neuronal models are essential for studying neurological physiology, disease
mechanisms and potential treatments. Most in vitro models lack controlled vasculature …

Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

Organ-on-a-chip devices are powerful modeling systems that allow researchers to
recapitulate the in vivo structures of organs as well as the physiological conditions those …

The stem cell niche at the perivascular space in human tissue plays a pivotal role in dictating
the overall fate of stem cells within it. Mesenchymal stem cells (MSCs) in particular …

Progress in understanding kidney disease mechanisms and the development of targeted
therapeutics have been limited by the lack of functional in vitro models that can closely …

Approximately 30% of drugs have failed in human clinical trials due to adverse reactions
despite promising pre-clinical studies, and another 60% fail due to lack of efficacy. One of …

The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human
physiology, these chips have the potential to increase the predictive power of preclinical …

Most biomedical and pharmaceutical research of the human vascular system aims to
unravel the complex mechanisms that drive disease progression from molecular to organ …

In vitro models of vasculature are of great importance for modelling vascular physiology and
pathology. However, there is usually a lack of proper spatial patterning of interacting …