The in vitro antimicrobial spectrum of piperacillin-tazobactam is described and the results of
clinical trials are summarized. Injectable products combining a β-lactam antibiotic with a β …

The pharmacokinetics of tazobactam (500 mg) administered intravenously alone were
compared with the pharmacokinetics of tazobactam coadministered with piperacillin (4 g) …

Six isolates each of Enterococcus faecium, Staphylococcus aureus, Staphylococcus
epidermidis, Streptococcus pyogenes, Stenotrophomonas maltophilia, Pseudomonas …

Piperacillin–tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity that includes Gram-positive and-negative aerobic and …

Objective: To report pharmacokinetic alterations and optimal dosing of piperacillin/
tazobactam in an obese patient. Case Summary: A 39-year-old morbidly obese (weight 167 …

Piperacillin combined with tazobactam at a fixed concentration (4 μg/ml) and a ratio (8: 1)
was tested against 5029 aerobic isolates and 447 fastidious organisms, including …

Abstract Background and Objectives Although dose optimization studies have been
performed for piperacillin and tazobactam separately, a combined integral analysis is not yet …

Abstract Twenty-nine British and Irish hospitals each collected up to 300 bacterial isolates
from in-patients. The organisms were identified by an appropriate API system or, for …

Combination with tazobactam substantially enhanced the activity of piperacillin against
routine isolates of staphylococci, various Enterobacteriaceae, Acinetobacter anitratus, and …

The pharmacokinetics of tazobactam and piperacillin in plasma and different tissues after a
30-min intravenous infusion of 4 g of piperacillin and 0.5 g of tazobactam were investigated …