Autophagy as a therapeutic target in cancer
N Chen, V Karantza - Cancer biology & therapy, 2011 - Taylor & Francis
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …
MicroRNA regulation of autophagy
LB Frankel, AH Lund - Carcinogenesis, 2012 - academic.oup.com
Macroautophagy (hereafter referred to as autophagy) is a tightly regulated intracellular
catabolic pathway involving the lysosomal degradation of cytoplasmic organelles and …
catabolic pathway involving the lysosomal degradation of cytoplasmic organelles and …
The role of autophagy in tumour development and cancer therapy
MT Rosenfeldt, KM Ryan - Expert reviews in molecular medicine, 2009 - cambridge.org
Autophagy is a catabolic membrane-trafficking process that leads to sequestration and
degradation of intracellular material within lysosomes. It is executed at basal levels in every …
degradation of intracellular material within lysosomes. It is executed at basal levels in every …
[HTML][HTML] Autophagy-regulating microRNAs and cancer
Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …
Autophagy mechanisms and roles: recent advances and implications
M Markaki, N Tavernarakis - The FEBS Journal, 2020 - Wiley Online Library
Autophagy is the main catabolic process by which cells recycle cytoplasmic components
and superfluous or damaged organelles to preserve metabolic homeostasis under normal …
and superfluous or damaged organelles to preserve metabolic homeostasis under normal …
[HTML][HTML] Autophagy and the cell cycle: a complex landscape
SG Mathiassen, D De Zio, F Cecconi - Frontiers in oncology, 2017 - frontiersin.org
Autophagy is a self-degradation pathway, in which cytoplasmic material is sequestered in
double-membrane vesicles and delivered to the lysosome for degradation. Under basal …
double-membrane vesicles and delivered to the lysosome for degradation. Under basal …
Recent insights into the function of autophagy in cancer
R Amaravadi, AC Kimmelman, E White - Genes & development, 2016 - genesdev.cshlp.org
Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …
Autophagy in cancer: having your cake and eating it
Autophagy, one of two major intracellular degradation pathways, plays a critical role in
energy homeostasis and the quality control of macromolecules and intracellular organelles …
energy homeostasis and the quality control of macromolecules and intracellular organelles …
[HTML][HTML] Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets
F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
dynamically degraded and re-processed to maintain physical homeostasis. However, the …
Autophagy: an adaptable modifier of tumourigenesis
S Wilkinson, KM Ryan - Current opinion in genetics & development, 2010 - Elsevier
Recently, autophagy has been demonstrated to modulate tumourigenesis and the response
to cancer therapy by regulating numerous cellular functions including maintenance of cell …
to cancer therapy by regulating numerous cellular functions including maintenance of cell …