Autophagy as a therapeutic target in cancer

N Chen, V Karantza - Cancer biology & therapy, 2011 - Taylor & Francis
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …

MicroRNA regulation of autophagy

LB Frankel, AH Lund - Carcinogenesis, 2012 - academic.oup.com
Macroautophagy (hereafter referred to as autophagy) is a tightly regulated intracellular
catabolic pathway involving the lysosomal degradation of cytoplasmic organelles and …

The role of autophagy in tumour development and cancer therapy

MT Rosenfeldt, KM Ryan - Expert reviews in molecular medicine, 2009 - cambridge.org
Autophagy is a catabolic membrane-trafficking process that leads to sequestration and
degradation of intracellular material within lysosomes. It is executed at basal levels in every …

[HTML][HTML] Autophagy-regulating microRNAs and cancer

D Gozuacik, Y Akkoc, DG Ozturk, M Kocak - Frontiers in oncology, 2017 - frontiersin.org
Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …

Autophagy mechanisms and roles: recent advances and implications

M Markaki, N Tavernarakis - The FEBS Journal, 2020 - Wiley Online Library
Autophagy is the main catabolic process by which cells recycle cytoplasmic components
and superfluous or damaged organelles to preserve metabolic homeostasis under normal …

[HTML][HTML] Autophagy and the cell cycle: a complex landscape

SG Mathiassen, D De Zio, F Cecconi - Frontiers in oncology, 2017 - frontiersin.org
Autophagy is a self-degradation pathway, in which cytoplasmic material is sequestered in
double-membrane vesicles and delivered to the lysosome for degradation. Under basal …

Recent insights into the function of autophagy in cancer

R Amaravadi, AC Kimmelman, E White - Genes & development, 2016 - genesdev.cshlp.org
Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Autophagy in cancer: having your cake and eating it

M Hoare, ARJ Young, M Narita - Seminars in cancer biology, 2011 - Elsevier
Autophagy, one of two major intracellular degradation pathways, plays a critical role in
energy homeostasis and the quality control of macromolecules and intracellular organelles …

[HTML][HTML] Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Autophagy: an adaptable modifier of tumourigenesis

S Wilkinson, KM Ryan - Current opinion in genetics & development, 2010 - Elsevier
Recently, autophagy has been demonstrated to modulate tumourigenesis and the response
to cancer therapy by regulating numerous cellular functions including maintenance of cell …