The tumor microenvironment (TME) is the environment around the tumor, including blood
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …

Tumor vasculature creates a hostile tumor microenvironment (TME) in vivo and nourishes
cancers, resulting in cancer progression and drug resistance. To mimic the biochemical and …

Molecular crosstalk between intra-tumor blood vessels and tumor cells plays many critical
roles in tumorigenesis and cancer metastasis. However, it has been very difficult to …

In vitro three-dimensional (3D) tumour models mimic natural cancer tissue in vivo, bridging
the gap between conventional 2D in vitro testing and animal models. Stromal and cancer …

Throughout the process of metastatic dissemination, tumor cells are continuously subjected
to mechanical forces resulting from complex fluid flows due to changes in pressures in their …

A tumor is composed of heterogeneous cell population, which is known as tumor stroma. In
particular, blood vessels have an indispensable role in the tumor microenvironment acting …

Cell–microenvironment interactions play a critical role in the transformation of normal cells
into cancer; however, the underlying mechanisms and effects are far from being well …

The “Tumor microenvironment”(TME) is a complex, interacting system of the tumor and its
surrounding environment. The TME has drawn more attention recently in attempts to …

Aberrant tumor vasculature leads to the malignant tumor microenvironment (TME) for tumor
progression. Research has found temporary tumor vascular normalization after treated with …

Tumor angiogenesis is controlled by the integrated action of physicochemical and biological
cues; however, the individual contributions of these cues are not well understood. We have …