Grape Powder Supplementation Attenuates Prostate Neoplasia Associated with Pten Haploinsufficiency in Mice Fed High‐Fat Diet

T Joshi, I Patel, A Kumar, V Donovan… - Molecular nutrition & …, 2020 - Wiley Online Library
Scope Previous studies have identified potent anticancer activities of polyphenols in
preventing prostate cancer. The aim of the current study is to evaluate the chemopreventive …

In vitro anticancer properties of table grape powder extract (GPE) in prostate cancer

A Kumar, M D'silva, K Dholakia, AS Levenson - Nutrients, 2018 - mdpi.com
Although the link between diet and cancer is complex, epidemiological data confirm that diet
is a risk factor for prostate cancer and indicate a reduced prostate cancer incidence …

Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice

K Raina, RP Singh, R Agarwal, C Agarwal - Cancer research, 2007 - AACR
Prostate cancer chemoprevention is an alternative and potential strategy to control this
malignancy. Herein, we evaluated the chemopreventive efficacy of grape seed extract (GSE) …

[HTML][HTML] High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene

J Liu, SK Ramakrishnan, SS Khuder, MK Kaw… - Molecular …, 2015 - Elsevier
Objective Association between prostate cancer and obesity remains controversial. Allelic
deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men …

Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin‐like growth factor binding protein‐3

RP Singh, AK Tyagi, S Dhanalakshmi… - … journal of cancer, 2004 - Wiley Online Library
Dietary intake of many fruits and vegetables has been shown to be associated with reduced
risk of cancer. We investigated the in vivo efficacy of grape seed extract (GSE, patented as …

Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKCϵ, Stat3, and Epithelial-to-Mesenchymal Transition …

BB Hafeez, JW Fischer, A Singh, W Zhong… - Cancer prevention …, 2015 - AACR
Prostate cancer continues to remain the most common cancer and the second leading
cause of cancer-related deaths in American males. The Pten deletions and/or mutations are …

Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice

B Velmurugan, RP Singh, N Kaul, R Agarwal… - Neoplasia, 2010 - Elsevier
Chemopreventive effects and associated mechanisms of grape seed extract (GSE) against
intestinal/colon cancer development are largely unknown. Herein, we investigated GSE …

Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, platelet factor-4

D Cervi, B Pak, NA Venier, LM Sugar, RK Nam… - BMC cancer, 2010 - Springer
Background Longstanding evidence implicates an inadequate diet as a key factor in the
onset and progression of prostate cancer. The purpose herein was to discover, validate and …

Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer

S Wang, J Wu, J Suburu, Z Gu, J Cai… - …, 2012 - academic.oup.com
A common treatment of advanced prostate cancer involves the deprivation of androgens.
Despite the initial response to hormonal therapy, eventually all the patients relapse. In the …

Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease

VM Adhami, IA Siddiqui, S Sarfaraz, SI Khwaja… - Clinical Cancer …, 2009 - AACR
Purpose: We have shown previously that oral feeding of green tea polyphenols (GTP) to
transgenic adenocarcinoma of the mouse prostate mice in a purely chemopreventive setting …