Eukaryotic cells use multiple, highly conserved mechanisms to contend with ultraviolet-light-
induced DNA damage. One important response mechanism is transcription-coupled repair …

In response to genotoxic stress, a transient arrest in cell-cycle progression enforced by the
DNA-damage checkpoint (DDC) signalling pathway positively contributes to genome …

The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the
machinery and its regulation remain poorly understood. Two principal elements of this …

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-
pathway of nucleotide excision repair that preferentially removes DNA lesions from the …

Transcription-coupled DNA repair removes bulky DNA lesions from the genome, and
protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins …

DEFECTS in human DNA repair proteins can give rise to the autosomal recessive disorders
xeroderma pigmentosum (XP) and Cockayne's syndrome (CS), sometimes even together1 …

THE RAD25 gene of Saccharomyces cerevisiae functions in nucleotide excision repair of
ultraviolet-damaged DNA and is also required for cell viability1. The RAD25 protein shows …

Rad23 is an evolutionarily conserved protein that is important for nucleotide excision repair
1, 2, 3. A regulatory role has been proposed for Rad23 because rad23 mutants are sensitive …

To maintain genome stability, cells respond to DNA damage by activating signalling
pathways that govern cell-cycle checkpoints and initiate DNA repair. Cell-cycle checkpoint …

The inability to repair DNA damage properly in mammals leads to various disorders and
enhanced rates of tumour development. Organisms respond to chromosomal insults by …