The sphingosine kinase 1 inhibitor, PF543, mitigates pulmonary fibrosis by reducing lung epithelial cell mtDNA damage and recruitment of fibrogenic monocytes
P Cheresh, SJ Kim, LS Huang, S Watanabe… - International journal of …, 2020 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are
urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and …
urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and …
[HTML][HTML] Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease,
wherein transforming growth factor β (TGF-β) and sphingosine-1-phosphate (S1P) …
wherein transforming growth factor β (TGF-β) and sphingosine-1-phosphate (S1P) …
Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-β1
Y Kono, T Nishiuma, Y Nishimura, Y Kotani… - American journal of …, 2007 - atsjournals.org
Transforming growth factor β (TGF-β) contributes to the progression of pulmonary fibrosis
through up-regulation of α–smooth muscle actin (α–SMA) as lung myofibroblast …
through up-regulation of α–smooth muscle actin (α–SMA) as lung myofibroblast …
[HTML][HTML] Deficiency of sphingosine-1-phosphate receptor 2 (S1P2) attenuates bleomycin-induced pulmonary fibrosis
SJ Park, DS Im - Biomolecules & Therapeutics, 2019 - ncbi.nlm.nih.gov
Abstract Sphingosine 1-phosphate (S1P) levels are often found to be elevated in serum,
bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and …
bronchoalveolar lavage, and lung tissue of idiopathic pulmonary fibrosis patients and …
Quercetin ameliorates pulmonary fibrosis by inhibiting SphK1/S1P signaling
X Zhang, Y Cai, W Zhang… - Biochemistry and Cell …, 2018 - cdnsciencepub.com
Idiopathic pulmonary fibrosis is an agnogenic chronic disorder with high morbidity and low
survival rate. Quercetin is a flavonoid found in a variety of herbs with anti-fibrosis function. In …
survival rate. Quercetin is a flavonoid found in a variety of herbs with anti-fibrosis function. In …
Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition
J Milara, R Navarro, G Juan, T Peiró, A Serrano… - Thorax, 2012 - thorax.bmj.com
Background Idiopathic pulmonary fibrosis (IPF) is characterised by the aberrant epithelial to
mesenchymal transition (EMT) and myofibroblast accumulation. Sphingosine-1-phosphate …
mesenchymal transition (EMT) and myofibroblast accumulation. Sphingosine-1-phosphate …
Sphingolipids in pulmonary fibrosis
LS Huang, V Natarajan - Advances in biological regulation, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by alveolar
epithelial cell injury, accumulation of fibroblasts/myofibroblasts and deposition of …
epithelial cell injury, accumulation of fibroblasts/myofibroblasts and deposition of …
Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages
J Zhao, Y Okamoto, Y Asano, K Ishimaru, S Aki… - PLoS …, 2018 - journals.plos.org
Idiopathic pulmonary fibrosis is a devastating disease with poor prognosis. The pathogenic
role of the lysophospholipid mediator sphingosine-1-phosphate and its receptor S1PR2 in …
role of the lysophospholipid mediator sphingosine-1-phosphate and its receptor S1PR2 in …
Endothelial-specific loss of sphingosine-1-phosphate receptor 1 increases vascular permeability and exacerbates bleomycin-induced pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease which leads to
significant morbidity and mortality from respiratory failure. The two drugs currently approved …
significant morbidity and mortality from respiratory failure. The two drugs currently approved …
Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis
SY Hong, YT Lu, SY Chen, CF Hsu, YC Lu… - Cell Death & …, 2023 - nature.com
Idiopathic pulmonary fibrosis is a progressive fibrotic disorder with no cure that is
characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay …
characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay …