The endocytic recycling compartment (ERC) is a series of perinuclear tubular and vesicular
membranes that regulates recycling to the plasma membrane. Despite evidence that cargo …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

The recycling endosome (RE) has long been considered as a sub-compartment of the early
endosome that recycles internalized cargoes to the plasma membrane. The RE is now …

Despite controversies and debates, some fundamental properties of endosomes become
apparent when comparing results from in vivo and in vitro strategies used to study …

Efficient sorting of the material internalized by endocytosis is essential for key cellular
functions and represents a, if not the, major trafficking pathway in mammalian cells …

After endocytosis, lysosomally targeted ligands pass through a series of endosomal
compartments. The endocytic apparatus that accomplishes this passage may be considered …

Cells internalize extracellular solutes, ligands and proteins and lipids in the plasma
membrane (PM) by endocytosis. The removal of membrane from the PM is counteracted by …

Cells rely on the correct sorting of endocytic ligands and receptors for proper function. Early
endosomes have been considered as the initial sorting station where cargos for degradation …

The endosomal membrane recycling system represents a dynamic conduit for sorting and re-
exporting internalized membrane constituents. The recycling system is composed of multiple …

Background Endocytosis allows the import and distribution of cargo into a series of
endosomes with distinct morphological and biochemical characteristics. Our current …