Adipocytes: impact on tumor growth and potential sites for therapeutic intervention
S Hefetz-Sela, PE Scherer - Pharmacology & therapeutics, 2013 - Elsevier
The prevalence of obesity has increased dramatically in recent decades, reaching epidemic
proportions. It is becoming clear that obesity is associated not only with type 2 diabetes …
proportions. It is becoming clear that obesity is associated not only with type 2 diabetes …
Insights into the link between obesity and cancer
SE Ackerman, OA Blackburn, F Marchildon… - Current obesity …, 2017 - Springer
Abstract Purpose of Review Adipocytes have adapted to store energy in the form of lipid and
also secrete circulating factors called adipokines that signal to other tissues to coordinate …
also secrete circulating factors called adipokines that signal to other tissues to coordinate …
Paracrine and endocrine effects of adipose tissue on cancer development and progression
J Park, DM Euhus, PE Scherer - Endocrine reviews, 2011 - academic.oup.com
The past few years have provided substantial evidence for the vital role of the local tumor
microenvironment for various aspects of tumor progression. With obesity and its …
microenvironment for various aspects of tumor progression. With obesity and its …
Signals from the adipose microenvironment and the obesity–cancer link—a systematic review
Obesity and its associated metabolic dysregulation are established risk factors for many
cancers. However, the biologic mechanisms underlying this relationship remain …
cancers. However, the biologic mechanisms underlying this relationship remain …
[HTML][HTML] The adipocyte–macrophage relationship in cancer: A potential target for antioxidant therapy
Obesity has emerged as a major public health concern with a staggering 39% worldwide
prevalence as of 2021. Given the magnitude of the problem and considering its association …
prevalence as of 2021. Given the magnitude of the problem and considering its association …
Update on adipose tissue and cancer
KA Brown, PE Scherer - Endocrine reviews, 2023 - academic.oup.com
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
Obesity and cancer: the role of dysfunctional adipose tissue
RCM Van Kruijsdijk, E Van Der Wall… - … , biomarkers & prevention, 2009 - AACR
Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …
[HTML][HTML] The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance
MN Duong, A Geneste, F Fallone, X Li, C Dumontet… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Growing evidence has raised the important roles of adipocytes as an active player in the
tumor microenvironment. In many tumors adipocytes are in close contact with cancer cells …
tumor microenvironment. In many tumors adipocytes are in close contact with cancer cells …
[HTML][HTML] Cancer-associated adipocytes: key players in breast cancer progression
Q Wu, B Li, Z Li, J Li, S Sun, S Sun - Journal of hematology & oncology, 2019 - Springer
Adipocytes are one of the primary stromal cells in many tissues, and they are considered to
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …
The dysfunctional adipocyte—a cancer cell's best friend
Z Zhang, PE Scherer - Nature Reviews Endocrinology, 2018 - nature.com
The interactions of adipocytes with tumour cells have been extensively scrutinized. The
adipocyte's mitogenic influence on tumour cells is attributed to several hormonal, growth …
adipocyte's mitogenic influence on tumour cells is attributed to several hormonal, growth …