Carboxylesterase and UDP‐glucuronosyltransferase‐mediated metabolism of irinotecan
(CPT‐11) has long been proposed to be responsible for its anti‐tumor activity and toxicity …

Objective: To develop an HPLC method for the simultaneous determination of irinotecan
(CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) in rat plasma …

Irinotecan hydrochloride (CPT‐11) is an effective anticancer drug, and its metabolic pathway
has been well studied. Nevertheless, in human hepatocellular carcinoma (HCC), its …

Irinotecan (CPT-11) is an important anticancer drug in management of advanced colon
cancer. A marked protective effect on CPT-11-induced blood and gastrointestinal toxicity is …

Alkalization of the intestinal tract by oral administration of sodium bicarbonate has been
reported to be a promising method for preventing delayed diarrhea, a dose-limiting toxicity in …

Irinotecan, or CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecine),
is a water-soluble derivative of camptothecine with promising activity against several types …

ABSTRACT Purpose: lrinotecan (CPT-11) is a prod rug of SN-38 and has been registered
for the treatment of advanced colorectal cancer. It is converted by the cytochrome P450 3A4 …

Recently, breast cancer resistance protein (BCRP/ABCG2) has been shown to limit the oral
absorption of its substrates in the intestine. The purpose of this study was to examine …

Ethyl-10-hydroxy-camptothecin (SN-38), an active metabolite of irinotecan hydrochloride
(CPT-11), has potent antitumor activity. Moreover, we have reported the strong antitumor …

Irinotecan (CPT-11) is a water-soluble camptothecin (CPT) derivative that has been recently
approved in the United States for patients as a first-line therapy in advanced colorectal …