Background. This study characterizes venous thrombosis in the mouse and examines the
important role that the adhesion molecules P-selectin and E-selectin and the anti …

The purpose of this study was to quantify the fibrin content of thrombi produced in a mouse
model of venous thrombosis and correlate this to thrombus mass. The role of P-selectin, E …

Venous thrombosis induces a detrimental inflammatory response in the vein wall. The
cytokine tumor necrosis factor-α (TNF) and the adhesion molecules, selectins, have been …

BACKGROUND: P-selectin inhibition with protein therapeutics such as antibodies or soluble
ligands given intravenously can decrease thrombosis in a mouse ligation model of venous …

Purpose: Venous thrombosis and inflammation are interrelated. P-selectin contributes to
activation of leukocyte-mediated inflammation. Therefore, we hypothesized that the …

BACKGROUND: Vein wall injury after thrombosis is multifactorial but seems dependent on
thrombus and local thrombotic and inflammatory mechanisms. We hypothesized that …

OBJECTIVES: P-selectin inhibition has been found to limit venous thrombosis. We
hypothesize that elevated levels of P-selectin will amplify thrombosis, mediated by …

INTRODUCTION: The objective of this study was to identify the direct relationship between
aging and selectin activation during acute venous thrombosis in mice of varying ages. We …

Background: Endothelial cell adhesion molecules such as E-selectin promote the capture of
neutrophils (PMN) in the microcirculation and initiate the inflammatory response. In contrast …

Purpose: The purpose of this study was to compare the efficacy of P-selectin inhibition with
standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein …