Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …

Although microglial activation occurs in inflammatory, degenerative and neoplastic central
nervous system (CNS) disorders, its role in pathogenesis is unclear. We studied this …

Communication within the glial cell ecosystem is essential for neuronal and brain health,–.
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …

Alzheimer's disease is characterized by the accumulation of amyloid-beta in plaques,
aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation …

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half
of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

Immune dysfunction is commonly associated with several neurological and mental
disorders. Although the mechanisms by which peripheral immunity may influence neuronal …

Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

The majority of patients with systemic lupus erythematosus (SLE) have high expression of
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …

We formulate a two-phase paradigm of autoimmunity associated with systemic lupus
erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR) …