Abstract Interferon-β (IFN-β) is the major treatment for multiple sclerosis. However, this
treatment is not always effective. Here we have found congruence in outcome between …

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of
hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic …

Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …

Alzheimer's disease is the world's most common dementing illness. Deposition of amyloid-β
peptide drives cerebral neuroinflammation by activating microglia,. Indeed, amyloid-β …

ALZHEIMER'S disease is the most common cause of progressive intellectual failure1. The
lesions that develop, called senile plaques, are extracellular deposits principally composed …

Microglia are brain macrophages and, as such, key immune-competent cells that can
respond to environmental changes. Understanding the mechanisms of microglia-specific …

The type-I interferon (IFN-α/β) response is critical to immunity against viruses and can be
triggered in many cell types by cytosolic detection of viral infection, or in differentiated …

Glucocorticoids are widely used to treat patients with autoimmune diseases such as
systemic lupus erythematosus (SLE),. However, regimens used to treat many such …

Increased blood levels of type I interferon (IFN-I) and expression of a broad signature of
gene transcripts that reflect induction by IFN-I are observed in many patients with systemic …

Microglia are specialized macrophages in the brain parenchyma that exist in multiple
transcriptional states and reside within a wide range of neuronal environments,,–. However …