Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …

Cancer cells are different from normal cells in their metabolic properties. Normal cells mostly
rely on mitochondrial oxidative phosphorylation to produce energy. In contrast, cancer cells …

Increased aerobic glycolysis in cancer, a phenomenon known as the Warburg effect, has
been observed in various tumor cells and represents a major biochemical alteration …

abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

Simple Summary Cancer represents unrestricted growth with the removal of conventional
brakes that control growth under normal conditions. This requires novel mechanisms to …

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark
of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg …

Tumor cells rely mainly on glycolysis for energy production even in the presence of sufficient
oxygen, a phenomenon termed the Warburg effect, which is the most outstanding …

Metabolic reprogramming and altered energetics have become an emerging hallmark of
cancer and an active area of basic, translational, and clinical cancer research in the recent …

Introduction One of the most distinctive hallmarks of cancer cells is increased glucose
consumption for aerobic glycolysis, which is called the Warburg effect. In recent decades …

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation
of ATP as a main source of their energy supply. This phenomenon is known as the Warburg …