Demethylbellidifolin isolated from Swertia bimaculate against human carboxylesterase 2: Kinetics and interaction mechanism merged with docking simulations
TT Liu, XK Huo, XG Tian, JH Liang, J Yi, XY Zhang… - Bioorganic …, 2019 - Elsevier
In this study, forty-nine kinds of traditional Chinese medicines (TCMs) were evaluated for
their inhibitory activities against human carboxylesterase 2 (HCE 2) using a human liver …
their inhibitory activities against human carboxylesterase 2 (HCE 2) using a human liver …
Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations
SS Song, CP Sun, JJ Zhou, L Chu - International journal of biological …, 2019 - Elsevier
In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …
Phytochemical constituents from Uncaria rhynchophylla in human carboxylesterase 2 inhibition: kinetics and interaction mechanism merged with docking simulations
YL Wang, PP Dong, JH Liang, N Li, CP Sun, XG Tian… - Phytomedicine, 2018 - Elsevier
Abstract Background Carboxylesterases (CEs) belong to the serine hydrolase family, and
are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional …
are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional …
A natural inhibitor from Alisma orientale against human carboxylesterase 2: Kinetics, circular dichroism spectroscopic analysis, and docking simulation
J Yi, R Bai, Y An, TT Liu, JH Liang, XG Tian… - International journal of …, 2019 - Elsevier
As a part of our searching for natural human carboxylesterase 2 (human CES 2) inhibitors
from traditional Chinese medicine, we found that the extract of Alisma orientale significantly …
from traditional Chinese medicine, we found that the extract of Alisma orientale significantly …
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2
Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
PF Song, YD Zhu, HY Ma, YN Wang, DD Wang… - Fitoterapia, 2019 - Elsevier
Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
[HTML][HTML] Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
YQ Song, RJ He, D Pu, XQ Guan, JH Shi… - Frontiers in …, 2021 - frontiersin.org
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
[HTML][HTML] Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1
Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …
[HTML][HTML] Novel protostane-type triterpenoids with inhibitory human carboxylesterase 2 activities
ZJ Zhang, XK Huo, XG Tian, L Feng, J Ning, XY Zhao… - RSC …, 2017 - pubs.rsc.org
The rhizomes of Alisma orientalis have been used for centuries in China and other Asian
countries as an effective herbal remedy. The phytochemical investigation of A. orientalis and …
countries as an effective herbal remedy. The phytochemical investigation of A. orientalis and …
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- human carboxylesterase 2 inhibitors
- interaction mechanism human carboxylesterase
- inhibition potentials human carboxylesterase
- inhibition behavior human carboxylesterase
- natural inhibitor human carboxylesterase
- selective inhibitor human carboxylesterase
- alisma orientale human carboxylesterase
- uncaria rhynchophylla human carboxylesterase
- molecular docking simulations
- pentacyclic triterpenoids human carboxylesterase
- phytochemical constituents human carboxylesterase
- ginkgo biloba human carboxylesterase
- interaction mechanism docking simulations
- inhibition potentials docking simulations
- natural inhibitor docking simulation
- alisma orientale docking simulation