In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

The histamine H4 receptor is a novel G-protein–coupled receptor with a unique
pharmacological profile. The distribution of H4 mRNA suggests that it may play a role in the …

The elucidation of the human genome has had a major impact on histamine receptor
research. The identification of the human H4 receptor by several groups has been …

The histamine H 4 receptor (H 4 R) was first noted as a sequence in genomic databases that
had features of a class A G-protein coupled receptor. This putative receptor was found to …

The human histamine receptors hH 1 R and hH 2 R constitute important drug targets, and
hH 3 R and hH 4 R have substantial potential in this area. Considering the species …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when
dinner is served or orchestrating the elements of inflammation after a mosquito bite …

We report the discovery, tissue distribution and pharmacological characterization of a novel
receptor, which we have named H4. Like the three histamine receptors reported previously …

H1 and H2 histamine receptor antagonists, although developed many decades ago, are still
effective for the treatment of allergic and gastric acid–related conditions. This article focuses …

The physiologic functions of histamine have been recognized for more than 100 years, yet
new roles are still being uncovered. Most importantly, a newly discovered receptor of the …