The monoamine histamine is one of the several chemical messengers involved in the
concerted regulation of (patho) physiological processes. In rat brain, histamine can be found …

The search for new and potent histamine H4 receptor ligands is leading to a steadily
increasing number of scientific publications and patent applications. Several interesting and …

In the present paper we report the genomic organization of the human histamine H3-
receptor gene, which consists of four exons spanning 5.5 kb on chromosome 20. Using …

The recent cloning and characterization of the human histamine H3 receptor cDNA marked
a significant step toward a greater understanding of the role of this receptor in the central …

Histamine exerts multiple biological actions through one of three receptor subtypes (H1, H2,
and H3). This review focuses on new developments regarding the structure and function of …

Constitutive activity has been mainly recorded for numerous overexpressed and/or mutated
receptors. The histamine H 3 receptor (H 3 R) is a target of choice to study the physiological …

This article reviews the development of our knowledge of the actions of histamine which
have taken place during the course of the 20th century. Histamine has been shown to have …

Histamine and antihistamines are so deeply woven into the fabric of allergic diseases that it
is sometimes difficult to see how this field could advance beyond our current, potent …

The classification of histamine receptors has to date been based on rigorous classical
pharmacological analysis, and as yet, the classification of the three histamine receptors that …

The identification of histamine H3 (H3R) and H4 (H4R) receptors some years ago revived
interest in histamine research and exposed attractive perspectives for the potential …