Autoimmune and inflammatory phenomena are characteristically present in systemic
sclerosis (SSc) and impact on dysregulated fibroblast extracellular matrix deposition …

ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

These observations provide a new paradigm for understanding the relationship between
immunity/inflammation and fibrosis. New therapeutics, including TLR agonists and …

Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Endothelial injury, obliterative microvascular lesions, and increased vascular wall thickness
are present in all involved organs in scleroderma. The vascular pathology is associated with …

Fibrosis in systemic sclerosis (SSc), a complex polygenic disease associated with
autoimmunity and proliferative/obliterative vasculopathy, shares pathobiologic features in …

Systemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by three
interconnected hallmarks (i) vasculopathy,(ii) aberrant immune activation, and (iii) fibroblast …

SSc is a multiphase autoimmune disease with a well-known triad of clinical manifestations
including vasculopathy, inflammation and fibrosis. Although a plethora of drugs has been …