In order to optimise the intrarectal administration of Quinimax®, this combination of
Cinchona alkaloids was administered intrarectally at 3 different dosages to 13 children with …

The increasing occurrence of chloroquine‐resistant Plasmodium falciparum in sub‐Saharan
Africa makes it essential to reconsider current recommendations for the treatment of …

Chloroquine-resistant Plasmodium falciparum has been spreading rapidly after its
emergence in 1988 in Yekepa. The in vivo and in vitro susceptibilities to quinine and …

Introduction. Quinine therapy for 7 days remains the mainstay for treating hospitalised
malaria cases in South Africa. However, limited resources, including available beds and …

We investigated the efficacy and toxic potential of antimalarial therapy regimens in 452
malaria patients treated between 1980 and 1990. Drug regimens in 330 non-immune …

Abstract In Msambweni, on the Kenyan coast 100 m S of Malindi, an area of chloroquine
resistant malaria where amodiaquine was previously found to be more effective than …

The sensitivity of Plasmodium falciparum to quinine in Nigeria was examined in vivo and in
vitro prior to the re-introduction of the drug into malaria therapy in that country in the face of …

In an attempt to avoid the complications associated with intramuscular quinine
administration, we assessed the intrarectal route. Sixty-six children aged from 2 to 10 years …

The response of P. Falciparum to chloroquine (CQ) and pyrimethamine-sulphadoxine (PSD)
in vivo was investigated in 173 indigenous uncomplicated malaria patients at Sololo …

Plasma quinine concentrations were measured in 21 Gambian children with severe
falciparum malaria after intramuscular administration of a 20 mg (salt) per kg loading dose of …