MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway
Chikungunya virus (CHIKV) epidemics around the world have created public health concern
with the unavailability of effective drugs and vaccines. This emphasizes the need for …
with the unavailability of effective drugs and vaccines. This emphasizes the need for …
P38 and JNK mitogen-activated protein kinases interact with chikungunya virus non-structural protein-2 and regulate TNF induction during viral infection in …
Chikungunya virus (CHIKV), a mosquito-borne Alphavirus, is endemic in different parts of
the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV …
the globe. The host macrophages are identified as the major cellular reservoirs of CHIKV …
Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex
SP Reid, SR Tritsch, K Kota, CY Chiang… - Emerging microbes & …, 2015 - Taylor & Francis
Chikungunya virus (CHIKV) is a re-emerging alphavirus which causes severe and
prolonged arthralgic febrile illness. The recent global spread of the virus and lack of …
prolonged arthralgic febrile illness. The recent global spread of the virus and lack of …
DNA damage response signaling is crucial for effective chikungunya virus replication
S Chatterjee, S Kumar, P Mamidi, A Datey… - Journal of …, 2022 - Am Soc Microbiol
Viruses utilize a plethora of strategies to manipulate the host pathways and hijack host
machineries for efficient replication. Several DNA and few RNA viruses are reported to …
machineries for efficient replication. Several DNA and few RNA viruses are reported to …
Targeting cap-dependent translation to inhibit chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down …
The 5′ capped, message-sense RNA genome of Chikungunya virus (CHIKV) utilizes the
host cell machinery for translation. Translation is regulated by eIF2 alpha at the initiation …
host cell machinery for translation. Translation is regulated by eIF2 alpha at the initiation …
The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase signaling
FS Varghese, B Thaa, SN Amrun, D Simarmata… - Journal of …, 2016 - Am Soc Microbiol
Chikungunya virus (CHIKV) has infected millions of people in the tropical and subtropical
regions since its reemergence in the last decade. We recently identified the nontoxic plant …
regions since its reemergence in the last decade. We recently identified the nontoxic plant …
Regulation of viral replication, apoptosis and pro-inflammatory responses by 17-AAG during Chikungunya virus infection in macrophages
Chikungunya virus (CHIKV) infection has re-emerged as a major public health concern due
to its recent worldwide epidemics and lack of control measures. Although CHIKV is known to …
to its recent worldwide epidemics and lack of control measures. Although CHIKV is known to …
MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo
The increase in disease incidences and persistent Chikungunya virus (CHIKV)-induced
arthritis have been a huge burden on public health globally. In the absence of specific …
arthritis have been a huge burden on public health globally. In the absence of specific …
Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection
Viruses use various strategies to modulate host pathways and take benefit of host
machineries for efficient infection. It has been reported that certain viruses manipulate the …
machineries for efficient infection. It has been reported that certain viruses manipulate the …
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication
R Abdelnabi, SN Amrun, LFP Ng, P Leyssen, J Neyts… - Antiviral Research, 2017 - Elsevier
We have shown previously that prostratin, a non-tumor promoting phorbol ester, inhibits
chikungunya virus (CHIKV)-induced cytopathic effects in vitro. Prostratin is a potent activator …
chikungunya virus (CHIKV)-induced cytopathic effects in vitro. Prostratin is a potent activator …