Background Early antibiotics are fundamental to sepsis management. Second-dose
antibiotic delays were associated with increased mortality in a recent study. Study objectives …

Objective: 1) Determine frequency and magnitude of delays in second antibiotic
administration among patients admitted with sepsis; 2) Identify risk factors for these delays; …

Background For patients with sepsis and septic shock, the initial administration of antibiotics
should occur as soon as possible, preferably within one hour of sepsis recognition. While …

Purpose: The aim of this study was to determine the incidence of significant delays in
administration of the second antibiotic dose in patients treated for severe sepsis and septic …

Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.
Objectives: To evaluate the association between antibiotic timing and mortality among …

Objectives: We sought to systematically review and meta-analyze the available data on the
association between timing of antibiotic administration and mortality in severe sepsis and …

Objective To evaluate whether delay between the first and second antibiotic administered for
suspected sepsis is associated with hospital mortality. Design Retrospective cohort. Setting …

Background Current sepsis guidelines recommend administration of antibiotics within 1 hour
of emergency department (ED) triage. However, the quality of the supporting evidence is …

Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …

Objective We aimed to investigate the effect of timely antibiotic administration on outcomes
in patients with severe sepsis and septic shock. Methods We analyzed data from a sepsis …