[HTML][HTML] Simultaneous in vivo measurements of the total hemoglobin, oxygen saturation, and tissue blood flow via hybrid near-infrared diffuse optical techniques

D Wang, L Wang, P Gao, R Shi, L Zhu, Q Peng, Z Li… - AIP Advances, 2019 - pubs.aip.org
Diagnosing a stroke at an emergency site is an important potential clinical application for
near-infrared light techniques. We have fabricated a hybrid diffuse optical device that …

Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism

D Milej, A Abdalmalak, A Rajaram… - …, 2020 - spiedigitallibrary.org
Significance: Near-infrared spectroscopy (NIRS) combined with diffuse correlation
spectroscopy (DCS) provides a noninvasive approach for monitoring cerebral blood flow …

Quantification of the severity of hypoxic-ischemic brain injury in a neonatal preclinical model using measurements of cytochrome-c-oxidase from a miniature …

P Kaynezhad, S Mitra, G Bale, C Bauer… - …, 2019 - spiedigitallibrary.org
We describe the development of a miniaturized broadband near-infrared spectroscopy
system (bNIRS), which measures changes in cerebral tissue oxyhemoglobin ([HbO2]) and …

Characterizing dynamic cerebral vascular reactivity using a hybrid system combining time-resolved near-infrared and diffuse correlation spectroscopy

D Milej, M Shahid, A Abdalmalak, A Rajaram… - Biomedical Optics …, 2020 - opg.optica.org
This study presents the characterization of dynamic cerebrovascular reactivity (CVR) in
healthy adults by a hybrid optical system combining time-resolved (TR) near-infrared …

Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults

MN Kim, T Durduran, S Frangos, BL Edlow… - Neurocritical care, 2010 - Springer
Background This study assesses the utility of a hybrid optical instrument for noninvasive
transcranial monitoring in the neurointensive care unit. The instrument is based on diffuse …

Non-invasive optical spectroscopy and imaging of human brain function

A Villringer, B Chance - Trends in neurosciences, 1997 - cell.com
Brain activity is associated with changes in optical properties of brain tissue. Optical
measurements during brain activation can assess haemoglobin oxygenation, cytochrome-c …

Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets

MR Stankovic, D Maulik, W Rosenfeld, PG Stubblefield… - 1999 - degruyter.com
Our objective was to study the development of experimental brain ischemia and hemorrhage
by real-time optical imaging. Optical imaging is based on the ability of near infrared light to …

Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow

M Diop, KM Tichauer, JT Elliott… - Advanced …, 2010 - spiedigitallibrary.org
A primary focus of neurointensive care is monitoring the injured brain to detect harmful
events that can impair cerebral blood flow (CBF). Since current non-invasive bedside …

Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans

DA Boas, K Chen, D Grebert, MA Franceschini - Optics letters, 2004 - opg.optica.org
We compare two geometries of sources and detectors for optimizing the diffuse optical
imaging resolution of brain activation in humans. Because of limitations in the instruments' …

[HTML][HTML] Perspective: prospects of non-invasive sensing of the human brain with diffuse optical imaging

S Fantini, B Frederick, A Sassaroli - Apl Photonics, 2018 - pubs.aip.org
Since the initial demonstration of near-infrared spectroscopy (NIRS) for noninvasive
measurements of brain perfusion and metabolism in the 1970s, and its application to …