Effects of cis and trans Genetic Ancestry on Gene Expression in African Americans
Variation in gene expression is a fundamental aspect of human phenotypic variation.
Several recent studies have analyzed gene expression levels in populations of different …
Several recent studies have analyzed gene expression levels in populations of different …
Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
We explored ancestry-related differences in the genetic architecture of whole-blood gene
expression using whole-genome and RNA sequencing data from 2,733 African Americans …
expression using whole-genome and RNA sequencing data from 2,733 African Americans …
Allelic variation in gene expression is common in the human genome
HS Lo, Z Wang, Y Hu, HH Yang, S Gere… - Genome …, 2003 - genome.cshlp.org
Variations in gene sequence and expression underlie much of human variability. Despite
the known biological roles of differential allelic gene expression resulting from X …
the known biological roles of differential allelic gene expression resulting from X …
Influence of human genome polymorphism on gene expression
T Pastinen, B Ge, TJ Hudson - Human molecular genetics, 2006 - academic.oup.com
Genetic variation, through its effects on gene expression, plays a crucial role in phenotypic
variation and disease susceptibility. Recent studies from our group and others have …
variation and disease susceptibility. Recent studies from our group and others have …
[PDF][PDF] Evaluation of genetic variation contributing to differences in gene expression between populations
Gene expression is a complex quantitative trait partially regulated by genetic variation in
DNA sequence. Population differences in gene expression could contribute to some of the …
DNA sequence. Population differences in gene expression could contribute to some of the …
Analysis of allelic differential expression in human white blood cells
PVK Pant, H Tao, EJ Beilharz, DG Ballinger… - Genome …, 2006 - genome.cshlp.org
Allelic variation of gene expression is common in humans, and is of interest because of its
potential contribution to variation in heritable traits. To identify human genes with allelic …
potential contribution to variation in heritable traits. To identify human genes with allelic …
[PDF][PDF] Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation
Full sequencing of individual human genomes has greatly expanded our understanding of
human genetic variation and population history. Here, we present a systematic analysis of …
human genetic variation and population history. Here, we present a systematic analysis of …
[PDF][PDF] Gene-expression variation within and among human populations
Understanding patterns of gene-expression variation within and among human populations
will provide important insights into the molecular basis of phenotypic diversity and the …
will provide important insights into the molecular basis of phenotypic diversity and the …
[PDF][PDF] Genetic architecture of gene expression in European and African Americans: an eQTL mapping study in GENOA
Most existing expression quantitative trait locus (eQTL) mapping studies have been focused
on individuals of European ancestry and are underrepresented in other populations …
on individuals of European ancestry and are underrepresented in other populations …
Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals
AL Price, A Helgason, G Thorleifsson… - PLoS …, 2011 - journals.plos.org
Family studies of individual tissues have shown that gene expression traits are genetically
heritable. Here, we investigate cis and trans components of heritability both within and …
heritable. Here, we investigate cis and trans components of heritability both within and …
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