Eukaryotic genes generate multiple RNA transcript isoforms though alternative transcription,
splicing, and polyadenylation. However, the relationship between human transcript diversity …

Background More and more experiments have shown that transcription and mRNA
processing are not two independent events but are tightly coupled to each other. Both …

Through alternative splicing, most human genes express multiple isoforms that often differ in
function. To infer isoform regulation from high-throughput sequencing of cDNA fragments …

The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …

The functional complexity of the human transcriptome is not yet fully elucidated. We report a
high-throughput sequence of the human transcriptome from a human embryonic kidney and …

Through alternative processing of pre-messenger RNAs, individual mammalian genes often
produce multiple mRNA and protein isoforms that may have related, distinct or even …

Alternative splicing of pre-mRNAs is central to the generation of diversity from the relatively
small number of genes in metazoan genomes. Auxiliary cis elements and trans-acting …

Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA
molecules from a single pre-mRNA with a prominent role in the development and function of …

Motivation: Understanding the occurrence and regulation of alternative splicing (AS) is a key
task towards explaining the regulatory processes that shape the complex transcriptomes of …

Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …