Alternative pre–messenger RNA (pre-mRNA) splicing plays important roles in development,
physiology, and disease, and more than half of human genes are alternatively spliced. To …

Alternative splicing essentially increases the diversity of the transcriptome and has important
implications for physiology, development and the genesis of diseases. Conventionally …

Alternative splicing (AS) is a common posttranscriptional process in eukaryotic organisms,
by which multiple distinct functional transcripts are produced from a single gene. The …

As a co-transcriptional process, RNA processing, including alternative splicing and
alternative polyadenylation, is crucial for the generation of multiple mRNA isoforms. RNA …

The combination of pervasive transcription and prolific alternative splicing produces a
mammalian transcriptome of great breadth and diversity. The majority of transcribed …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

There is growing evidence that mammalian genomes produce thousands of transcripts that
do not encode proteins, and this RNA class might even rival the complexity of mRNAs. There …

Background The multifaceted control of gene expression requires tight coordination of
regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the …

Background Alternative pre-mRNA splicing (AS) is widely used by higher eukaryotes to
generate different protein isoforms in specific cell or tissue types. To compare AS events …

Alternative RNA splicing is a known phenomenon, but we still do not have a complete
catalog of isoforms that explain variability in the human transcriptome. We have made …