In alternative expression analysis by sequencing (ALEXA-seq), we developed a method to
analyze massively parallel RNA sequence data to catalog transcripts and assess differential …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

Proper control of the transcriptome is key for diverse aspects of gene expression, cellular
functions and development, and its disruption can result in disease. A rapidly accumulating …

Alternative splicing is a major contributor to genomic complexity, disease, and development.
Previous studies have captured some of the characteristics that distinguish alternative …

We analyzed the FANTOM2 clone set of 60,770 RIKEN full-length mouse cDNA sequences
and 44,122 public mRNA sequences. We developed a new computational procedure to …

Following the original reports of pre‐mRNA splicing in 1977, it was quickly realized that
splicing together of different combinations of splice sites–alternative splicing–allows …

Regulation of gene expression by RNA processing mechanisms is now understood to be an
important level of control in mammalian cells. Regulation at the level of RNA transcription …

The dogmatic view of RNA as a mere necessity in the transfer of information between DNA
and proteins has during recent years come into question. Novel approaches and new …

Background RNA-seq data is currently underutilized, in part because it is difficult to predict
the functional impact of alternate transcription events. Recent software improvements in full …

The rate of RNA polymerase II (Pol II) elongation can influence splice site selection in
nascent transcripts, yet the extent and physiological relevance of this kinetic coupling …